Zaviralci SGLT-2
نویسندگان
چکیده
منابع مشابه
The Human Kidney Low Affinity Na + / glucose Cotransporter SGLT 2
The major reabsorptive mechanism for D-glucose in the kidney is known to involve a low affinity high capacity Na+/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1, and which has a Na' to glucose coupling ratio of 1:1. Here we provide the first molecular evidence for this renal D-glucose reabsorptive mechanism. We report the characterization of a previou...
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Accustomed to managing diabetes with agents that mostly act by modulating the secretion and actions of insulin, with the advent of sodium-glucose linked transporter-2 (SGLT-2) inhibitors, physicians are now aware that the kidney also needs to be considered in the spectrum of action of anti-hyperglycaemic agents. Though familiar with the need for dose adjustment when prescribing many of our curr...
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Glucosuria, the presence of glucose in the urine, has long been regarded as a consequence of uncontrolled diabetes. However, glucose excretion can be induced by blocking the activity of the renal sodium-glucose cotransporter 2 (SGLT-2). This mechanism corrects hyperglycemia independently of insulin. This article provides an overview of the paradigm shift that triggered the development of the SG...
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Despite the development of several pharmacological agents over the past decade, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and sodium glucose cotransporter 2 (SGLT2) inhibitors, the management of hyperglycaemia in patients with type 2 diabetes remains challenging. SGLT2 inhibitors are a new class of glucose-lowering agents that have a u...
متن کاملUse of SGLT-2 inhibitors in the treatment of type 2 diabetes mellitus.
INTRODUCTION Diabetes mellitus is one of the most common chronic diseases in the world, with high morbidity and mortality rates, resulting in a greatly negative socioeconomic impact. Although there are several classes of oral antidiabetic agents, most of the patients are outside the therapeutic goal range. OBJECTIVE To review the use of SGLT-2 inhibitors in the treatment of type 2 diabetes me...
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ژورنال
عنوان ژورنال: Slovenian Medical Journal
سال: 2018
ISSN: 1581-0224,1318-0347
DOI: 10.6016/zdravvestn.2705